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For dieting phases, one might alternately combine stanozolol with a nonaromatizing steroid such as 150 mg per week of a trenbolone ester or 200-300 mg of Primobolan)and also consider an oral diuretic such as d-dihydrotestosterone hydrochloride 200 mg (or d-dihydrotestosterone) per day (although the evidence is inconclusive regarding the effects of this drug on weight loss during weight loss dieting). In this regard, there appears to be some evidence that chronic use of nonaromatizing steroids can decrease the growth factor secretagogue activity of GH (Tann et al., 1991; Pusch et al., 1996), with subsequent decreases in GH receptor binding and the secretion of IGF-1. One possible adverse effect of chronic treatment is the occurrence of weight gain that is greater than the weight loss from the use of the nonaromatizing steroid (Tann et al., 1991; Pusch et al., 1996). It is not clear if this effect is due to the presence of additional free testosterone or a reduction in the amount of testosterone present in the tissues due to the absence of the steroid; however, it has been observed by numerous investigators that GH increases the plasma free testosterone level as well as its binding affinity to the binding protein of the IGF-1 receptor (Pusch et al., 1996). Related Article: